Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Antiulcer Activity of Dehydroabietic Acid Derivatives
HIROSHI WADASHINICHI KODATOMASATOSHI KAWAMORITAMIO MORIKAWAHIDEO NAKAIMIKIO TAKEDASEIICHI SAITOYUICHI ONODAHAJIME TAMAKI
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1985 Volume 33 Issue 4 Pages 1472-1487

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Abstract

Derivatives of dehydroabietic acid (1) having a hydrophilic moiety (such as amino, carbamoyl, carbamoyloxy, ureido, sulfamoyl, or sulfo) at positions 12 and/or 18 of the dehydroabietane nucleus were prepared and tested for antiulcer activity by means of antisecretory and antipepsin assays in rats. Among these compounds, the salts of 12-sulfodehydroabietic acid (62, 63, and 64) were found to exhibit remarkably high antipepsin activity without aldosterone-like activity.

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© The Pharmaceutical Society of Japan
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