Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
Properties of Hydrazones of Hydralazine and Colorimetric Determination of Hydralazine Hydrochloride with p-Dimethylaminocinnamaldehyde Based on Solvent Extraction
KENICHIRO NAKASHIMAKAHORU SHIMADASHUZO AKIYAMA
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Keywords: solvent extraction
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1985 Volume 33 Issue 4 Pages 1515-1521

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Abstract

The hydrazones of hydralazine hydrochloride with various aromatic aldehydes were prepared and their spectral properties were examined. On the basis of the above examination, a colorimetric determination of hydralazine hydrochloride with p-dimethylaminocinnamaldehyde based on solvent extraction (CHCl3) was developed. The calibration curve obtained was linear up to 9.8 μg/ml of hydralazine hydrochloride. The method was successfully applied for the analysis of commercial pharmaceutical preparations (tablet and injection). The contents found were 106±2% (tablet) and 100±1% (injection) of the labeled values.

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© The Pharmaceutical Society of Japan
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