Synthesis of a New Amino Acid-Antibiotic, Oxetin and Its Three Stereoisomers

YUTAKA KAWAHATA; SUGURU TAKATSUTO; NOBUO IKEKAWA; MASATSUNE MURATA; SATOSHI OMURA

doi:10.1248/cpb.34.3102

YUTAKA KAWAHATA, SUGURU TAKATSUTO, NOBUO IKEKAWA, MASATSUNE MURATA, SATOSHI OMURA

Author information

Keywords: stereoselective ring-opening reaction

JOURNAL FREE ACCESS

1986 Volume 34 Issue 8 Pages 3102-3110

DOI https://doi.org/10.1248/cpb.34.3102

Details

Abstract

Oxetin (1a), a unique antibiotic having an oxetane ring, and its three stereoisomers (1b, 1c, and 1d) were synthesized from the known aldehyde (6) by utilizing a highly regio- and stereoselective epoxide ring-opening reaction. The biological activities of these oxetin stereoisomers were compared.

Corresponding author

Register with J-STAGE for free!