Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
MILD OXIDATION OF ALLYLIC AND BENZYLIC ALCOHOLS WITH 5-ARYLIDENE BARBITURIC ACID DERIVATIVES AS A MODEL OF REDOX COENZYMES
Kiyoshi TanakaXing ChengTeiji KimuraFumio Yoneda
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JOURNALS FREE ACCESS

1986 Volume 34 Issue 9 Pages 3945-3948

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Abstract

Under neutral conditions 5-arylidene 1, 3-dimethylbarbituric acid effectively oxidizes allylic and benzylic alcohols to the corresponding carbonyl compounds.There is a close relationship between oxidizing ability and electron density on the aromatic ring. The mechanism of this oxidation involves hydride transfer from the alcohol.

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© The Pharmaceutical Society of Japan
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