AN EFFICIENT 3 (C) -ACYLATION OF TETRAMIC ACIDS INVOLVING ACYL MIGRATION OF 4 (O) -ACYLATES

Abstract

3 (C) -Acylation of 3-unsubstituted tetramic acids with carboxylic acid has been achieved by two sequential reactions in one flask : (1) 4 (O) -acylation in the presence of DCC and a catalytic amount of DMAP, and (2) 4 (O) →3 (C) acyl-migration promoted by adding Et₃N.