Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
Antitumor Action of Shiitake (Lentinus edodes) Fruit Bodies Orally Administered to Mice
HIROAKI NANBAKANICHI MORITETSURO TOYOMASUHISATORA KURODA
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1987 Volume 35 Issue 6 Pages 2453-2458

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Abstract

The powdered fruit bodies of shiitake (Lentinus edodes) showed antitumor activity when given orally to mice. The growth of tumors, both syngeneic and allogeneic, was inhibited by 57.9 to 78.6% in shiitake-fed mice. The degree of inhibition was proportional to the consumption of the experimental diet (L-feed) and was evident even when the administration was started from the 7th day after tumor implantation. The inhibition of tumor growth was mainly due to a glucan contained in the fruit bodies, but the lipid fracton also had inhibitory effects, although mild. Feeding of the fruit bodies to mice in the diet was found to augment both the ability of macrophages to phagocytose latex particles and the spreading activity of the macrophages.

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© The Pharmaceutical Society of Japan
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