Synthesis of Leukotriene B₃ Derivatives

Abstract

Four geometric isomers of a leukotriene B₃ derivative (1b, 2b, 3b, 4b) and their nor derivatives (1a, 2a, 3a, 4a) were synthesized selectively from a common starting material by the same methodology using the Wittig-Horner reaction. All optical isomers of all-trans nor leukotriene B₃ dimethylamide (1a), one of the eight compounds, were also synthesized.