Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Studies on Peptides. CLIII. Application of the Hard-Acid Deprotecting Procedure to the Synthesis of Ovine Corticotropin Releasing Factor (oCRF)
KENICHI AKAJI, MOTOYOSHI NOMIZU, KAZUHIDE WATANABE, SUSUMU FUNAKOSHI, HIROO IMURA, TOSHIHIKO TSUKADA, JUNICHI FUKATA, HIROMICHI NAKAMUTA, MASAO KOIDA, NOBUTAKA FUJII, HARUAKI YAJIMA
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キーワード: ovine corticotropin releasing factor synthesis, β-cycloheptylaspartate, thioanisole-mediated deprotection, hard-acid deprotection, trimethylsilyl trifluoromethanesulfonate deprotection, base-catalyzed succinimide formation, immunoreactive corticotropin release
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1987 年 35 巻 9 号 p. 3859-3865

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A 41-residue peptide corresponding to the entire amino acid sequence of ovine corticotropin releasing factor (oCRF) was synthesized by assembling ten peptide fragments of established purity, followed by hard-acid deprotection with 1 M trimethylsilyl trifluoromethanesulfonate in trifluoroacetic acid. β-Cycloheptylaspartate was employed to minimize base-catalyzed succinimide formation. When tested by in vivo assay, synthetic oCRF was as active as synthetic hCRF in terms of ability to release immunoreactive corticotropin.

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