Spectrophotometric Determination of Halogen-Containing Organic Pharmaceuticals Using1, 5-Bis (6-methyl-4-pyrimidyl) carbazone. IV

Abstract

A spectrophotometric method for the determination of chlorine, bromine or iodine ion by using1, 5-bis (6-methy1-4-pyrimidyl) carbazone has been established. The ranges of determination were0.355-3.55ppm of Cl-, 0.799-7.99ppm of Br and1.27-12.7ppm of F. The proposed method could be applied to the analyses of various halogen-containing organic compounds, including sulfur-containing compounds. Eleven commercial pharmaceutical preparations gave precision (R.S.D.) values in the range of0.2%to5.6%(replicate analysis), when they were processed by the oxygen flask combustion method.