An Approach to the Stereoselective Synthesis of Nidifocene : Regio- and Stereoselective Synthesis of vic-trans-Bromochlorocyclohexane Ring System

Abstract

(±)-(2R^*, 5aS^*, 7R^*, 8R^*, 9aR^*)- and (2R^*, 5aS^*, 7S^*, 8S^*, 9aR^*)-7-Bromo-8-chloro-decahydro-2, 5a-methano-1-benzoxepin (1 and 2), the 11, 11-dedimethyl-7-demethylene derivative of nidifocene and its isomer, were stereoselectively synthesized via the bromohydrin 3 and 4 starting from the exo-diene 14.