Condensed Thienopyrimidines. IV. : Synthesis and Gastric Antisecretory Activity of 2, 3-Dihydro-5H-oxazolothienopyrimidine Derivatives

Abstract

2, 3-Dihydro-5H-oxazolo[3, 2-a]thieno[3, 2-d]-(2a-d), [3, 4-d]-(2e-h), and [2, 3-d]pyrimidine derivatives (2i, j) were synthesized and evaluated for gastric antisecretory activity. These analogues (2) were prepared stepwise starting from formylthiophenecarbamates (4). The structure-activity relationships of these compounds are discussed.