Fasciculic Acids A, B and C as Calmodulin Antagonists from the Mushroom Naematoloma fasciculare

Akira TAKAHASHI; Genjiro KUSANO; Tomihisa OHTA; Yasushi OHIZUMI; Shigeo NOZOE

doi:10.1248/cpb.37.3247

Chemical and Pharmaceutical Bulletin

Online ISSN : 1347-5223
Print ISSN : 0009-2363

Fasciculic Acids A, B and C as Calmodulin Antagonists from the Mushroom Naematoloma fasciculare

Akira TAKAHASHI, Genjiro KUSANO, Tomihisa OHTA, Yasushi OHIZUMI, Shigeo NOZOE

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Keywords: Basidiomycetes, Naematoloma fasciculare, fasciculol ester, fasciculic acid A, fasciculic acid B, fasciculic acid C, calmodulin antagonist, W-7

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Volume 37 (1989) Issue 12 Pages 3247-3250

DOI https://doi.org/10.1248/cpb.37.3247

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Abstract

Three new fasciculol esters, fasciculic acids A (1), B (2) and C (3), having potent calmodulin antagonistic activity were isolated from the toxic mushroom Naematoloma fasciculare (Fr.) KARST. Their structures were elucidated on the basis of spectral and chemical evidence.

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