Isolation and Structures of Two New Indoloditerpenes Related to Aflavinine from a Microsclerotium-Producing Strain of Aspergillus flavus

Abstract

Along with paspalinine (3), aflatrem (4), aflavinine (5), and dihydroxyaflavinine (6), two new indoloditerpenes, monohydroxyaflavinine (7) and monohydroxyisoaflavinine (8), were isolated from the methylene chloride extract of a microsclerotium-producting strain of Aspergillus flavus, which has activity to produce aflatoxins.The structures of the above compounds were determined on the basis of spectroscopic investigations and X-ray crystal analyses of monohydroxyaflavinine (7) acetone solvate and monohydroxyisoaflavinine (8).