An Improved Optical Resolution of 3-Acetylthio-2-methylpropionic Acid by Use of a New Chiral Amine, N-Isopropyl(phenylalaninol)

Tadahiro SAWAYAMA; Masatoshi TSUKAMOTO; Takashi SASAGAWA; Shunsuke NARUTO; Jun-ichi MATSUMOTO; Hitoshi UNO

doi:10.1248/cpb.37.1382

Chemical and Pharmaceutical Bulletin

Online ISSN : 1347-5223
Print ISSN : 0009-2363

An Improved Optical Resolution of 3-Acetylthio-2-methylpropionic Acid by Use of a New Chiral Amine, N-Isopropyl(phenylalaninol)

Tadahiro SAWAYAMA, Masatoshi TSUKAMOTO, Takashi SASAGAWA, Shunsuke NARUTO, Jun-ichi MATSUMOTO, Hitoshi UNO

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Keywords: angiotensin converting enzyme inhibitor, resolving agent, ternary phase diagram, eutectic composition

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Volume 37 (1989) Issue 5 Pages 1382-1383

DOI https://doi.org/10.1248/cpb.37.1382

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Abstract

(S)-3-Acetylthio-2-methylpropionic acid was obtained in a good yield by an effective optical resolution with a newly synthesized chiral amine, (S)-N-isopropyl(phenylalaninol), which was readily derived from (S)-phenylalaninol, as a resolving agent.

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