Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Metabolic Products of Aspergillus terreus. X. : Biosynthesis of Asterriquinones
Kunizo ARAIYuzuru YAMAMOTO
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1990 Volume 38 Issue 11 Pages 2929-2932

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Abstract

The biosynthesis of asterriquinones in Aspergillus terreus var. africanus IFO 8835 has been elucidated. Enzymatic activities for the formation of demethyl asterriquinone-D (asterriquinone synthase), prenyltransferase and methyltransferase on asterriquinone were detected in a crude extract of mycelium. Demethyl asterriquinone is biosynthesized from indolepyruvic acid and then methylation of the hydroxyl of group of the quinone moiety occurs.Prenylation proceeds simultaneously at the C-7, C-2 and N-1 positions of the indole moiety.

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© The Pharmaceutical Society of Japan
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