DESIGN AND SYNTHESIS OF AN OPIOID RECEPTOR PROBE : MODE OF BINDING OF S-ACTIVATED (-)-6β-SULFHYDRYLDIHYDROMORPHINE WITH THE SH GROUP IN THE μ-OPIOID RECEPTOR

Ken KANEMATSU; Ryo NAITO; Yasuyuki SHIMOHIGASHI; Motonori OHNO; Tomio OGASAWARA; Masayasu KURONO; Kunio YAGI

doi:10.1248/cpb.38.1438

Chemical and Pharmaceutical Bulletin

Online ISSN : 1347-5223
Print ISSN : 0009-2363

DESIGN AND SYNTHESIS OF AN OPIOID RECEPTOR PROBE : MODE OF BINDING OF S-ACTIVATED (-)-6β-SULFHYDRYLDIHYDROMORPHINE WITH THE SH GROUP IN THE μ-OPIOID RECEPTOR

Ken KANEMATSU, Ryo NAITO, Yasuyuki SHIMOHIGASHI, Motonori OHNO, Tomio OGASAWARA, Masayasu KURONO, Kunio YAGI

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Keywords: opioid recepter, sulfhydryl group, sulfhydrylmorphine, thiol-disulfide exchange reaction, guinea pig ileum, opioid receptor probe

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Volume 38 (1990) Issue 5 Pages 1438-1440

DOI https://doi.org/10.1248/cpb.38.1438

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Abstract

An S-activated sulfhydrylmorphine derivative was synthesized, and its linking to the μ-opioid receptor through a disulfide bond was demonstrated.

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