Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Phenolic Compounds from Stem Bark of Acanthopanax senticosus and Their Pharmacological Effect in Chronic Swimming Stressed Rats
西部 三省木下 英弘武田 秀勝岡野 五郎
ジャーナル フリー

1990 年 38 巻 6 号 p. 1763-1765


Ten phenolic compounds, isofraxidin (1), (+)-syringaresinol-di-O-β-D-glucoside (2), syringin (3), chlorogenic acid (4), isofraxidin-7-O-β-D-glucoside (5), 2, 6-dimethoxy-p-benzoquinone (6), (+)-pinoresinol-O-β-D-glucoside (7), (+)-syringaresinol-O-β-D-glucoside (8), (+)-pinoresinol-di-O-β-D-glucoside (9), and (+)-medioresinol-di-O-β-D-glucoside (10), were isolated from the stem bark of Acanthopanax senticosus HARMS and identified, respectively.The aquenous extract of the stem bark exhibited a prolonging effect on the exercise time to exhaustion in chronic swimming stressed rats. The effect on the exercise time in the chronic swimming stressed rats was respectively tested for compounds 2 and 4, which are major constituents of the stem bark. As a result, it was indicated that compound 2 is the compound responsible for part of the pharmacological effect which the aqueous extract of the stem bark showed.

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