Studies on Cardiotonic Agents. II. : Synthesis of Novel Phthalazine and 1, 2, 3-Benzotriazine Derivatives

Yuji NOMOTO; Hiroyuki OBASE; Haruki TAKAI; Masayuki TERANISHI; Joji NAKAMURA; Kazuhiro KUBO

doi:10.1248/cpb.38.2179

著者情報

キーワード: positive inotropic activity, cardiotonic agent, structure-activity relationship, phthalazine, 1, 2, 3-benzotriazine, piperidine

ジャーナルフリー

1990 年 38 巻 8 号 p. 2179-2183

DOI https://doi.org/10.1248/cpb.38.2179

詳細

抄録

A series of phthalazine and 1, 2, 3-benzotriazine derivatives which have heterocyclylpiperidino groups was synthesized and tested for cardiotonic activity in anesthetized dogs. Several 6, 7-dimethoxyphthalazine derivatives showed relatively potent cardiotonic activity comparable to that of amrinone.

責任著者(Corresponding author)

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