Interaction between Polyethylene Films and Bromhexine·HCl in Solid Dosage Form. III. Prevention of Drug Sorption by Improving Manufacturing Processes

Abstract

The interaction between polyethylene containers and bromhexine·HCl solid dosage forms prepared by different methods was studied. It was found that bromhexine·HCl tablets prepared by the wet method (kneading) had more drug remaining than those prepared by the dry method. The sorption of drug to polyethylene was influenced by the kneading solvents used, and the most effective solvent in preventing sorption was methanol, which has high solubility for bromhexine·HCl. A group mixture of bromhexine·HCl with crystalline cellulose was effective inhibiting the sorption of bromhexine to polyethylene. This was explained in terms of the monomolecular dispersion of bromhexine molecules within the network of cellulose molecules in the ground mixture.