Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Relative Inhibitory Activity of Berberine-Type Alkaloids against 12-ο-Tetradecanoylphorbol-13-acetate-Induced Inflammation in Mice
安川 憲滝戸 道夫池川 哲郎島田 文武竹内 美恵子中川 滋木
ジャーナル フリー

1991 年 39 巻 6 号 p. 1462-1465


Forty eight derivatives of berberine-type alkaloids were examined for their inhibition activity against the induction of edema on mouse ear by application of 12-O-tetradecanoylphorbol-13-acetate (TPA). Berberine had an inhibitory effect against TPA-induced ear edema at a grade corresponding to those of quercetin, caffeine and cepharanthine.berberine derivatives had stronger inhibitory activity than palmatine derivatives. 9-N, N-Diphenylcarbamoyl derivatives of both 9-demethylberberine and 9-demethylpalmatine had rather strong activity. These inhibitory activities are about ten times the activity of the respective mother compounds. Furthermore, 9-N-monophenylcarbamoyl derivatives and N, N-diphenylcarbamoyl chloride are found to have no effect

© The Pharmaceutical Society of Japan
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