Repandiol, a New Cytotoxic Diepoxide from the Mushrooms Hydnum repandum and H. repandum var. album

Akira TAKAHASHI; Takeshi ENDO; Shigeo NOZOE

doi:10.1248/cpb.40.3181

著者情報

キーワード: cytotoxic diepoxide, repandiol, (2R, 3R, 8R, 9R)-4, 6-decadiyne-2, 3 : 8, 9-diepoxy-1, 10-diol, mushroom, basidiomycete, Hydnum repandum, Hydnum repandum var. album, structure elucidation, total synthesis

ジャーナルフリー

1992 年 40 巻 12 号 p. 3181-3184

DOI https://doi.org/10.1248/cpb.40.3181

詳細

抄録

Repandiol, a new cytotoxic diepoxide has been isolated from the mushrooms Hydnum repandum and H. repandum var. album. The chemical structure was elucidated as (2R, 3R, 8R, 9R)-4, 6-decadiyne-2, 3 : 8, 9-diepoxy-1, 10-diol on the basis of spectroscopic analysis. The structure was confirmed by the synthesis of optically active repandiol. Repandiol displayed potent cytotoxic activity against various tumor cells.

責任著者(Corresponding author)

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