Induction of Dyspnea by Aerosol of Endothelin-1/Histamine or /Methacholine in the Conscious Guinea Pig

Tomoyuki KOSHI; Yoshinori ETOH; Takahiro TORII; Yasushi WADA; Mitsuteru HIRATA; Masao OHKUCHI; Tetsuro OKABE

doi:10.1248/cpb.40.1064

Tomoyuki KOSHI, Yoshinori ETOH, Takahiro TORII, Yasushi WADA, Mitsuteru HIRATA, Masao OHKUCHI, Tetsuro OKABE

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Keywords: endothelin-1, histamine, indomethacin, dyspnea, conscious guinea pig

JOURNAL FREE ACCESS

1992 Volume 40 Issue 4 Pages 1064-1065

DOI https://doi.org/10.1248/cpb.40.1064

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Abstract

The inhalation of aerosol of endothelin-1 (ET-1) induced dyspneal behavior in conscious guinea pigs pretreated with histamine or methacholine inhalation, although it was not observed by the inhalation of ET-1 alone. The dyspneal response to the inhalation of ET-1/histamine was potently inhibited by indomethacin, but it was not affected by nifedipine or diphenhydramine.

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