NUCLEOSIDES AND NUCLEOTIDES 111. THERMAL STABILITY OF OLIGODEOXYRIBONUCLEOTIDE DUPLEXES CONTAINING N6-HYDROXYADENINE IN SUBSTITUTION FOR ADENINE

Hisayoshi NISHIO; Akira ONO; Akira MATSUDA; Tohru UEDA

doi:10.1248/cpb.40.1355

Chemical and Pharmaceutical Bulletin

Online ISSN : 1347-5223
Print ISSN : 0009-2363

NUCLEOSIDES AND NUCLEOTIDES 111. THERMAL STABILITY OF OLIGODEOXYRIBONUCLEOTIDE DUPLEXES CONTAINING N⁶-HYDROXYADENINE IN SUBSTITUTION FOR ADENINE

Hisayoshi NISHIO, Akira ONO, Akira MATSUDA, Tohru UEDA

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Keywords: N⁶-hydroxyadenine, oligonucleotide, thermal denaturation, mutation

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Volume 40 (1992) Issue 5 Pages 1355-1357

DOI https://doi.org/10.1248/cpb.40.1355

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Abstract

An oligodeoxyribonucleotide containing N⁶-hydroxyadenine (H) has been synthesized. An order of Tms of duplexes consisting of 5'd'(CCTGGTAHCAGGTCC)3' : 5'd(GGACCTGNTACCAGG) (N = A, G, T, C) was H : T > H : G > H : A > H : C.

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