Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
Isolation of Novel Lignans, Heteroclitins F and G, from the Stems of Kadsura heteroclita, and Anti-lipid Peroxidative Actions of Heteroclitins A-G and Related Compounds in the in Vitro Rat Liver Homogenate System
Xiu-Wei YANGHirotsugu MIYASHIROMasao HATTORITsuneo NAMBAYasuhiro TEZUKATohru KIKUCHIDao-Feng CHENGuo-Jun XUTochihiko HORIMichael EXTINEHiroshi MIZUNO
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1992 Volume 40 Issue 6 Pages 1510-1516


From the stems of Kadsura heteroclita, two new lignans named heteroclitins F and G were isolated and their structures were determined by various spectroscopic means including an X-ray diffraction method. Dibenzocyclo-octadiene type lignans and related compounds isolated from the stems of K. heteroclita, potently inhibited the lipid peroxidation in the rat liver homogenate stimulated by Fe2+-ascorbic acid, CCl4-reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) and adenosine 5'-diphosphate-NADPH.

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