A New Synthetic Route to 1, 5-Benzothiazepines. Synthesis of Derivatives of Diltiazem
1992 年 40 巻 8 号 p. 1986-1989
詳細
1992 年 40 巻 8 号 p. 1986-1989
Several derivatives of diltiazem (9a-c) have been synthesized from the oxamate (6) through the carbon-carbon ring closure of the sulfur-stabilized benzylic anion and the ester carbonyl group, followed by stereoselective reduction of the C3-carbonyl of the 1, 5-benzothiazepine-dione (7).
