Studies on Thermophile Products. IV. Structural Elucidation of Cytotoxic Substance, BS-1, Derived from Bacillus stearothermophilus

Yasuhiro KOHAMA; Kentaro IIDA; Taro SEMBA; Tsutomu MIMURA; Akira INADA; Keishi TANAKA; Tsutomu NAKANISHI

doi:10.1248/cpb.40.2210

小濱靖弘, 飯田健太郎, 仙波太郎, 三村務, 稲田昭, 田中啓詞, 中西勤

著者情報

キーワード: B. stearothermophilus, cytotoxicity, structure, bis(2-hydroxyethyl) trisulfide, leukemia, mastocytoma, lymphoma

ジャーナルフリー

1992 年 40 巻 8 号 p. 2210-2211

DOI https://doi.org/10.1248/cpb.40.2210

詳細

抄録

A new cytotoxic substance designated as BS-1 was isolated from the autolysate and culture filtrate of Bacillus stearothermophilus UK563. On the basis of spectral data, the structure of BS-1 was determined as bis(2-hydroxyethyl) trisulfide and confirmed by direct comparison with the synthetic compound. BS-1 exhibited potent cytotoxicity against leukemia P388-D1, leukemia P388, mastocytoma P815, lymphoma EL4 and lymphoma MOLT4.

責任著者(Corresponding author)

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