Thermochemical Aspects of Partition. Quantitative Structure Activity Relationships of Benzyldimethylalkylammonium Chlorides

Abstract

As an extension of our recent studies on the relationships between thermochemical aspects of partition and biological activities, enthalpies and entropies of partition have been determined for 17 congeners of the titled quaternary ammonium chlorides, and the novel hydrophobic parameters, P_H and P_S, have been assigned. The regression equations using these parameters are discussed against the biological activities of pasteurization : a parabolic model is built up with regard to the P_H and P_S terms, which gives an improved result compared to a linear model.