Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
Cytotoxic Sesquiterpenes from Nardostachys chinensis
Hideji ITOKAWAKoichi MASUYAMAHiroshi MORITAKoichi TAKEYA
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1993 Volume 41 Issue 6 Pages 1183-1184

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Abstract

Five cytostatic sesquiterpenes, desoxo-narchinol-A (1), nardosinone (2), debilon (3), nardosinonediol (4) and kanshone A (5), were isolated from the roots and rhizomes of Nardostachys chinensis (Valerianaceae). The steric structure of 1 was determined by nuclear Overhauser effects (NOEs) and the exciton chirality method. All five showed cytotoxic activity against P-388 cells and the structure-activity relationship of 1 was also discussed.

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