Studies of Reactive Inorganic Layered Compounds with Drugs. I. Intercalation of Phosphatidylcholine Containing Indomethacin into Synthetic Mica

Yoshiteru WATANABE; Yasushi KANZAKI; Makiko FUJII; Yoshiaki MATSUMOTO; Ikuyo SHIOZAKI; Tatsuo TANAKA; Mitsuo MATSUMOTO

doi:10.1248/cpb.42.163

渡辺善照, 神崎 [ヤスシ], 藤井まき子, 松本宜明, 塩崎郁代, 田中龍夫, 松本光雄

著者情報

キーワード: synthetic mica, intercalation, indomethacin-phosphatidylcholine solid dispersion, inorganic layered compounds, X-ray diffraction analysis

ジャーナルフリー

1994 年 42 巻 1 号 p. 163-166

DOI https://doi.org/10.1248/cpb.42.163

詳細

抄録

The interaction between a sodium-type synthetic mica (Na-TSM), a model material of reactive layered compounds, and phosphatidylcholine (PC) in a solid dispersion (IM-PC) with indomethacin (IM), a model drug, was investigated using X-ray diffraction analysis. It was found that IM-PC interacts with Na-TSM, and can be immobilized in the interlayer space by means of heating. When IM mole fractions in IM-PC increased from 0.25 to 0.5, the amount of IM intercalated into Na-TSM increased correspondingly from 5-18%. Consequently, it was determined that inorganic layered compounds, such as Na-TSM, intercalated with drugs in PC can be obtained.

責任著者(Corresponding author)

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