Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
STRUCTURES OF NOVEL BUFADIENOLIDES IN THE EGGS OF A TOAD, Bufo marinus
Toshifumi AKIZAWATsutomu MUKAIMotomi MATSUKAWAMasanori YOSHIOKAJennifer F. MORRISVincent P. BUTLER
Author information
JOURNALS FREE ACCESS

Volume 42 (1994) Issue 3 Pages 754-756

Details
Download PDF (511K) Contact us
Abstract

In this paper, we report chemical structures of five compounds including four novel polyhydroxylated cardiac steroids in the eggs of a toad, Bufo marinus. These cardiac steroids were purified by high-performance liquid chromatography, and their structrues were determined to be 11α, 19-dihydroxytelocinobufagin (I), 11α-hydroxytelocinobufagin (II), 11α, 19-dihydroxymarinobufagin (III), 11α-hydroxymarinobufagin (IV) and 19-hydroxytelocinobufagin (V) on the basis of spectral data of nuclear magnetic resonance and mass spectroscopy. All the five compounds showed biological activity, as tested by inhibition of Na+, K+-ATPase activity and of [3H]ouabain binding to the receptor on Na+, K+-ATPase. This is the first finding of bufadienolides as cardiac steroids in animal eggs.

Information related to the author
© The Pharmaceutical Society of Japan
Previous article Next article

Recently visited articles
feedback
Top