Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Stomachic Principles in Ginger. III. An Anti-ulcer Principle, 6-Gingesulfonic Acid, and Three Monoacyldigalactosylglycerols, Gingerglycolipids A, B, and C, from Zingiberis Rhizoma Originating in Taiwan
吉川 雅之山口 祥子国見 久美子松田 久司奥野 安洋山原 條二村上 啓寿
ジャーナル フリー

1994 年 42 巻 6 号 p. 1226-1230


An anti-ulcer constituent, 6-gingesulfonic acid, and three monoacyldigalactosylglycerols, gingerglycolipids A, B, and C, were isolated from Zingiberis Rhizoma, the dried rhizome of Zingiber officinale ROSCOE which was cultivated in Taiwan, together with (+)-angelicoidenol-2-O-β-D-glucopyranoside. Based on chemical reactions and physicochemical evidence, the structures of 6-gingesulfonic acid, gingerglycolipids A, B, and C have been determined.In addition, the absolute stereostructure of (+)-angelicoidenol-2-O-β-D-glucopyranoside was clarified on the basis of its synthesis from d-borneol. 6-Gingesulfonic acid showed weaker pungency and more potent anti-ulcer activity than 6-gingerol and 6-shogaol.

© The Pharmaceutical Society of Japan
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