Fungal Metabolites. XVII. Synthesis and NMR Study of Ion Channel-Forming Peptides, Trichosporin B-VIa and Its Derivative

Abstract

A membrane-modifying peptide antibiotic, trichosporin B-VIa, having catecholamine secretion-inducing activity on bovine adrenal chromaffin cells has been synthesized. Aib¹⁴-Trichosporin B-VIa, in which Pro¹⁴ was replaced by Aib, has also been synthesized to modify the secondary structure of trichosporin B-VIa. Sequience-specific ¹H-NMR assignments of both peptides in methanol were achieved by using two-dimensional NMR techniques.