Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Bioactive Saponins and Glycosides. V. Acylated Polyhydroxyolean-12-ene Triterpene Oligoglycosides, Camelliasaponins A1, A2, B1, B2, C1, and C2, from the Seeds of Camellia japonica L. : Structures and Inhibitory Activity on Alcohol Absorption
Masayuki YOSHIKAWAToshiyuki MURAKAMISatoshi YOSHIZUMINobutoshi MURAKAMIJohji YAMAHARAHisashi MATSUDA
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1996 Volume 44 Issue 10 Pages 1899-1907

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Abstract

Acylated polyhydroxyolean-12-ene triterpene oligoglycosides, camelliasaponins A1, A2, B1, B2, C1, and C2, were isolated from the seeds of Camellia japonica L. The structures of six camelliasaponins were elucidated on the basis of chemical and physicochemical evidence. Camelliasaponins B1, B2, C1, and C2 were found to exhibit inhibitory activity on ethanol absorption. By comparison of the inhibitory activities for camelliasaponins with those for desacyl-camelliasaponins, acyl groups such as the angeloyl or tigloyl group were found to be essential to exerting the activity.

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© The Pharmaceutical Society of Japan
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