Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
Indonesian Medicinal Plants. XVII. Characterization of Quassinoids from the Stems of Quassia indica
Isao KITAGAWATaifo MAHMUDKo-ichi YOKOTAShinsaku NAKAGAWATadanori MAYUMIMotomasa KOBAYASHIHirotaka SHIBUYA
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1996 Volume 44 Issue 11 Pages 2009-2014

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Abstract

Four new quassinoids named samaderines X (1), Y (2), and Z (3), and indaquassin X (5), and a new C19 quassinoid glycoside, 2-O-glucosylsamaderine C (10), together with five known quassinoids, samaderines B (7), C (8), and E (4), indaquassin C (6), and simarinolide (9), were isolated from the stems of Quassia indica (Simaroubaceae), an Indonesian medicinal plant. The chemical structures of these quassinoids have been elucidated on the bases of their chemical and physicochemical properties. Samaderines X (1), Z (3), E (4), and B (7) were shown to exhibit significant growth-inhibitory activity against the cultured malarial parasite Plasmodium falciparum (a chloroquine- resistant K1 strain), and 1-8 were shown to exhibit in vitro cytotoxicity (IC50 : 0.04-1.00 μg/ml) against KB cells. Samaderines X (1), B (7), and C (8), as well as indaquassin X (5), exhibited inhibitory activity in the in vitro endothelial cell-neutrophil leukocyte adhesion assay, whereas samaderines X (1) and B (7) were found to exhibit significant anti-inflammatory activity.

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