Optical Resolution by Preferential Crystallization of(RS)-α-Amino-γ-butyrolactone Hydrochloride

Tadashi SHIRAIWA; Hideya MIYAZAKI; Atsushi OHTA; Yukitaka WAKI; Masahiro YASUDA; Toshimitsu MORISHITA; Hidemoto KUROKAWA

doi:10.1248/cpb.44.2322

Tadashi SHIRAIWA, Hideya MIYAZAKI, Atsushi OHTA, Yukitaka WAKI, Masahiro YASUDA, Toshimitsu MORISHITA, Hidemoto KUROKAWA

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Keywords: α-amino-γ-butyrolactone, conglomerate, optical resolution, preferential crystallization

JOURNAL FREE ACCESS

1996 Volume 44 Issue 12 Pages 2322-2325

DOI https://doi.org/10.1248/cpb.44.2322

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Abstract

(RS)-α-Amino-γ-butyrolactone hydrochloride [(RS)-ABL·HCl] was found to exist as a conglomerate based on the infrared spectrum, solubility, and melting point. Optical resolution by preferential crystallization of(RS)-ABL·HCl was achieved to yield (R)- and (S)-ABL·HCl. The obtained (R)- and (S)-ABL·HCl were recrystallized, taking into account the solubility of (RS)-ABL·HCl to give optically pure (R)- and (S)-ABL·HCl.

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