Enzymatic Hydrolysis of meso(syn-syn)-1, 3, 5-Triacetoxy-2, 4-dimethylpentane and Acetylation of meso(syn-syn)-3-Benzyloxy-2, 4-dimethylpentane-1, 5-diol by Lipase

Shinji NAGUMO; Takayuki ARAI; Hiroyuki AKITA

doi:10.1248/cpb.44.1391

Shinji NAGUMO, Takayuki ARAI, Hiroyuki AKITA

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Keywords: meso(syn-syn)-1, 3, 5-triacetoxy-2, 4-dimethylpentane, meso(syn-syn)-3-benzyloxy-2, 4-dimethylpentane-1, 5-diol, enzymatic hydrolysis, enzymatic acetylation

JOURNAL FREE ACCESS

1996 Volume 44 Issue 7 Pages 1391-1394

DOI https://doi.org/10.1248/cpb.44.1391

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Abstract

Chiral inductions of meso triacetate (4) and meso diol (15) were carried out on the basis of enzymatic reaction using lipase to give chiral synthons having three consecutive chiral centers with high enantiomeric excess.

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