ELECANACIN, A NOVEL NEW NAPHTHOQUINONE FROM THE BULB OF ELEUTHERINE AMERICANA

Hidemitsu HARA; Naoki MARUYAMA; Shinsuke YAMASHITA; Yasuhisa HAYASHI; Kuo-Hsiung LEE; Kenneth F. BASTOW; CHAIRUL; Ryuji MARUMOTO; Yasuhiro IMAKURA

doi:10.1248/cpb.45.1714

Hidemitsu HARA, Naoki MARUYAMA, Shinsuke YAMASHITA, Yasuhisa HAYASHI, Kuo-Hsiung LEE, Kenneth F. BASTOW, CHAIRUL, Ryuji MARUMOTO, Yasuhiro IMAKURA

Author information

Hidemitsu HARA
Naoki MARUYAMA
Shinsuke YAMASHITA
Yasuhisa HAYASHI
Kuo-Hsiung LEE
Kenneth F. BASTOW
CHAIRUL
Ryuji MARUMOTO
Yasuhiro IMAKURA
Author's Organization：
Faculty of Sciences, Naruto University of Education
Faculty of Sciences, Naruto University of Education
Faculty of Sciences, Naruto University of Education
Faculty of Sciences, Joetsu University of Education
Natural Products, School of Pharmacy, University of North Carolina
Natural Products, School of Pharmacy, University of North Carolina
Research & Development Centre for Biology, Indonesian Institute of Science
Animal Health Research Laboratories, Agro Division, Takeda Chemical Industries LTD.,
Faculty of Sciences, Naruto University of Education

Keywords: Eleutherine americana, Iridaceae, elecanacin, isoeleutherol, human topoisomerase II inhibitor, anti-HIV

JOURNAL FREE ACCESS

1997 Volume 45 Issue 10 Pages 1714-1716

DOI https://doi.org/10.1248/cpb.45.1714

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Abstract

A novel new naphthoquinone called elecanacin (9) and a new naphthalene called isoeleutherol (10) were isolated from the bulb of Eleutherine americana MERR. et HEYNE (Iridaceae), together with two known naphthoquinones (2 and 3). The structures were determined by spectroscopic methods including the 2D-NMR techniques. Eleutherin (2) showed interesting inhibitory activity against human topoisomerase II, and isoeleutherin (3) and isoeleutherol (10) showed inhibitory activity against HIV.

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