Manoamine Oxidase Inhibitory constituents from Anixiella micropertusa

Haruhiro FUJIMOTO; Yoko SATOH; Kentaro YAMAGUCHI; Mikio YAMAZAKI

doi:10.1248/cpb.46.1506

Haruhiro FUJIMOTO, Yoko SATOH, Kentaro YAMAGUCHI, Mikio YAMAZAKI

Author information

Keywords: fungal metabolite, Ascomycete, Anixiella micropertusa, monoamine oxidase inhibitor, xanthone, anthraquinone

JOURNAL FREE ACCESS

1998 Volume 46 Issue 10 Pages 1506-1510

DOI https://doi.org/10.1248/cpb.46.1506

Details

Abstract

Two known naturally-occurring constituents, 1, 7-dihydroxy-3-methylxanthone and emodin, were isolated from as Ascomycete Anixiella micropertusa as inhibitors of mouse monoamine oxidase (MAO), together with four non-MAO inhibitory components, including two novel compounds, 1, 7-Dihydroxy-3-methylxanthone and emodin inhibited MAO moderately, and IC₅₀ value were calculated to be 2.06×10^-5 and 3.70×10^-5 M, respectively.

Corresponding author

Register with J-STAGE for free!