Effect of the Carbamoyl Group Attached to an Axial Ligand Portion of a Novel Bleomycin Model on a Dioxygen Activating Reaction

Abstract

A Fe complex of a novel bleomycin model compound bearing a diaminopropionamide (DAPA) moiety as the axial ligand and a long alkyl chain as the steric factor around the 6th coordination site promoted reversible redox reaction and exhibited high oxygen activating ability. Kinetic analysis of the redox reaction in the presence of dioxygen and a reducing agent revealed that the presence of the carbamoyl group on the DAPA moiety facilitates the oxygenation-activation process of the Fe(II) complex, and the reduction process of the resulting Fe(III) complex.