Spermic Acid Diester Derivatives as Pharmacological Carries for Long-Term Controlled Nitric Oxidase Delivery

Abstract

Water-insoluble diazeniumdiolates with extended nitric oxide (NO) release half-lives were synthesized based on diester of spermic acid. These diesters were prepared via Michael addition reactions from 1, 4-diaminobutane and various acrylate esters. synthesis and NO release profiles of dimethyl, diethyl, dibutyl, dihexyl, and dilauryl spermate diazeniumdiolates are reported.