Sequence Specificity of DNA Cleavage by Bisnetropsin-Linked Hydroxamic Acid-Metal Complexes : Highly Specific cleavage by Ferrous Complexes

Abstract

Bisnetropsin-linked hydroxamic acids (BHNA) were shown to cleave DNA strands at a single residue with a preferred binding orientation in the presence of ferrous ion. In constrast, the corresponding cerium (III) complexes cleaved DNA with low sequence specificity.