Synthesis of Trimethylhydroquinone Derivatives as Anti-allergic Agents with Anti-oxidative Actions

Nobuhide KAWASAKI; Hideki MIYATAKA; Mayumi NISHIKI; Hitoshi MATSUMOTO; Naoki INAGAKI; Hiroichi NAGAI; Toshio SATOH

doi:10.1248/cpb.47.177

Nobuhide KAWASAKI, Hideki MIYATAKA, Mayumi NISHIKI, Hitoshi MATSUMOTO, Naoki INAGAKI, Hiroichi NAGAI, Toshio SATOH

著者情報

キーワード: anti-allergic agent, anti-oxidative action, 5-lipoxygenase, passive cutaneous anaphylaxis, 4-[4-[4-(diphenylmethyl)-1-piperazinyl]butoxy]-2, 3, 6-trimethylphenol

ジャーナルフリー

1999 年 47 巻 2 号 p. 177-181

DOI https://doi.org/10.1248/cpb.47.177

詳細

抄録

A novel series of trimethylhydroquinone derivatives was synthesized and evaluated for their anti-lipid peroxidation activity in rat liver microsomes, inhibition of rat basophilic leukemia-1 (RBL-1) cell 5-lipoxygenase and 48h homologous passive cutaneous anaphylaxis (PCA) activity in rats. 4-[4-[4-(Diphenylmethyl)-1-piperazinyl]butoxy]-2, 3, 6-trimethylphenol (9c) exhibited the ability to inhibit Fe³⁺-ADP induced NADPH dependent lipid peroxidation (IC₅₀=5.3×10^-7M), 5-lipoxygenase ((IC₅₀=3.5×10^-7M) and PCA reaction (57% inhibition at 100 mg/kg p.o.).

責任著者(Corresponding author)

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