Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Organic Phosphates. VIII. A Novel Synthesis of Riboflavin 5'-Phosphate.
浮田 忠之進長沢 金蔵
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1959 年 7 巻 4 号 p. 465-468

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The alcoholysis reaction of catechol cyclic phosphate (CCP) (I) with polyols reported in the preceding paper was applied to phosphorylation of riboflavin. The latter was phosphorylated to give a mixture of riboflavin 5'-phosphate (FMP) (Vc) and riboflavin 4', 5'-cyclic phosphate in a yield of 75∼78%. After acid hydrolysis the pure riboflavin 5'-phosphate was obtained by zone electrophoresis without any loss of the product during isolation.
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© The Pharmaceutical Society of Japan
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