On the Action of Substituted Azaindolizines on Microorganisms. III. Action of Aminated Azaindolizines on Lactic Acid Bacteria.

Abstract

Action of aminated azaindolizines on Lactobacillus casei and Streptococcus faecalis was compared with that of several diaminopyrimidine compounds. All compounds exhibited more pronounced effect on St. faecalis than on L. casei. Growth inhition caused by these compounds was reversed in the decreasing order by thymine, leucovorin, and folic acid. These results suggested that C=N bond between 1- and 8a-positions in 1-azaindolizine molecule might have an effect similar to amino group on the lactic acid bacteria.