Synthesis of Potential Anticancer Agents. VII. 6-Nitro- and 6-Amino-s-triazolo [2, 3-α] pyrimidines.

Abstract

By nitration of s-triazolo [2, 3-α] pyrimidine derivatives, four kinds of 6-nitro derivatives (Va, VIa, VIIa, and VIIIa) were obtained. These nitro compounds were converted to the corresponding 6-amino derivatives by catalytic reaction and the nature of the amino group at 6-position was examined. 2-Acetamido-1, 3-dicarbonyl compounds were condensed with 5-amino-s-triazole (IX) into 6-acetamido-s-triazolo [2, 3-α] pyrimidines (VIc, VIIc, and VIIIc), which were converted into the corresponding 6-amino derivatives by hydrolysis.