Correlation between Insulin-like Growth Factor-I and Obesity Index during Inpatient Treatment in Anorexia Nervosa in Childhood and Adolescence

Abstract

We studied whether insulin-like growth factor-I (IGF-I) is attributable to nutrition during inpatient treatment in anorexia nervosa (AN) in childhood and adolescence. Nineteen Japanese females with AN, aged 12-19, were enrolled in this study. They were admitted to our hospital during 1993∼2003 and treated by the "Keio Method". They had complete bed rest during the first 2 mo of treatment. We studied a possible correlation between serum IGF-I level and obesity index (OI) by using the Spearman rank correlation test. The serum IGF-I level (SDS) and OI (%) was significantly positively correlated on admission (p=.009), at 1 mo (p=.0227), and 2 mo (p=.0063) after admission. These results indicate that the serum IGF-I level is determined by nutritional status in AN in childhood and adolescence under complete bed rest.