Cell Structure and Function
Online ISSN : 1347-3700
Print ISSN : 0386-7196
ISSN-L : 0386-7196
Tubulin: 30 Years Later
Crystallographic Structure of Tubulin : Implications for Dynamics and Drug Binding
Kenneth H. DowningEva Nogales
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1999 Volume 24 Issue 5 Pages 269-275

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Abstract

The structure of tubulin, recently solved by electron crystallography, has given a first look at the molecular basis for some of the properties of tubulin and microtubules that have been observed over the last decades. We discuss how the structure relates to some of these properties, and how inferences about drug binding sites can explain some of the effects of the drugs on tubulin. Microbulules can form a highly dynamic system that requires careful tuning of the stability and properties of tubulin and its interactions with its many ligands. Understanding these interactions can provide fundamental information on the regulation of the microtubule system.

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© 1999 by Japan Society for Cell Biology
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