Online ISSN : 1348-7019
Print ISSN : 0011-4545
Assessment of the Potential Clastogenic/Aneugenic Risk of Casearia sylvestris Extract Using in Vivo Assays
Edson Luis MaistroSergio Faloni de AndradeMarilane Aparecida Puras
ジャーナル オープンアクセス

2007 年 72 巻 4 号 p. 401-407


Casearia sylvestris (Flacourtiaceae) is a plant which grows in wild and has been widely used in folk medicine. In this study, clastogenic/aneugenic properties of Casearia sylvestris crude ethanolic extract were evaluated using in vivo chromosomal aberrations (CAs) and micronucleus (MN) assays in rodents. The animals were treated by gavage with 3 concentrations of the extract: 150, 300 and 500 mg/kg body weight. Bone marrow cells from Wistar rats were collected 24 h after having been submitted to the MN and CAs test. Peripheral blood cells from Swiss mice were collected 48 and 72 h after having been submitted to the MN test. The results show that C. sylvestris extract does not induce a significant increase in mean values for micronucleated polychromatic erythrocytes (MNPCE) in Swiss mice and Wistar rats, or CAs in rat bone marrow cells, at the 3 tested doses, indicating that the extract showed no clastogenic/aneugenic effects on chromosomes of the rodent cells tested.

© (2007), The Japan Mendel Society
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