Action du Téniposide sur l'Ultrastructure de Chromosomes Lymphocytaires Humains

Abstract

Action of Teniposide on the Ultrastructural Aspect of Human Metaphasic Lymphocytes Chromosomes
Teniposide tested “in vitro” on human lymphocytes cultures of 24 hours, at various concentrations, inhibits the formation of the mitotic metaphase plates and brings about thickening of the chromosomal fiber, observed in electron microscopy.
After 3 hours of exposition in the culture, teniposide induces numerous chromosomal aberrations: gaps, breaks, exchanges.