Analysis of Chromosomal Abnormalities at Anaphase-Telophase Induced by Sodium Fluoride In Vitro
1987 年 52 巻 4 号 p. 889-893
詳細
1987 年 52 巻 4 号 p. 889-893
The effect of treatment of cultured Don Chinese hamster cells with sodium fluoride has been investigated with respect to induction of chromosomal abnormalities. Exposure of Don Chinese hamster cells to sodium fluoride (25μg/ml, 50μg/ml, and 75μg/ml) induced a higher frequency of chromosomal abnormalities as compared to control. The observed abnormalities included were bridges, bridges with fragments, sidearm bridges and tripolar and multipolar anaphases. Bridges and fragments were the most common type of abnormalities observed in all treatments.
